Art of Protest was selected for the project with £38,000 of support after York City Council received 11 proposals for a set of Front Street murals as part of a wider regeneration effort.
The company will work with community members to create the design for the mural, according to a City Council report on the committee's commissioning decision.
According to the report, the call for designs attracted interest from all over the world, and Art of Protest was selected because it received the highest score for its proposed mural idea.
This follows the approval of a Front Street revitalization plan in September, ahead of the March deadline for disbursing government funds to fund the works.
The regeneration has been supported by £570,000 from parliament's UK Shared Prosperity Fund (UKSPF) pot of £5.1m, allowing the government to collect any unspent funds from March onwards.
The project will see the removal of 90 of Front Street's 131 bollards following backlash after they were installed in January 2023.
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It will be replaced with planters and the intersection will be widened as part of construction that began in October and will continue through February.
The city council learned in September that it was in talks with local artists to design the mural.
At the time, there were calls to use local artists instead of hiring artists from outside York.
It will be a new gateway to Front Street, and its design will reflect the larger area, according to a council report on the committee.
In conjunction with the painting of the mural, eight benches will also be renovated by Art of Protest.
The council's report on the decision said both projects were estimated to cost £34,770, with £38,000 allocated to cover unforeseen changes.