North Yorkshire Police said officers from the Yorkshire and Humber Regional Organized Crime Unit (YHROCU) seized around 50kg of suspected cocaine over the weekend.
Officers, assisted by North Yorkshire Police and West Yorkshire Police, stopped the vehicle on the A1(M) at Scotch Corner at around 9am on Saturday (November 30).
Approximately 24 kg of what appeared to be cocaine was recovered and one man was arrested.
A further search of the property in Easingwold resulted in the recovery of around 25kg of suspected cocaine and the arrest of two further men.
A 31-year-old man of Henfield Way, Easingwold; a 20-year-old man of Beechburn Crescent, Robbie, Merseyside; and a 49-year-old man of Childwall Lane, Robbie, Merseyside, for the following purposes: He was charged with possession. We supply Class A medicines.
All three were remanded to appear before Leeds magistrates on Monday and further remanded to appear at Leeds Crown Court on January 3.
Chief Inspector Fiona McEwan, of North Yorkshire Police, said: “Tampting organized crime remains North Yorkshire Police's top priority. We remain committed to disrupting criminals and removing those responsible from our streets. I'm here.
“We urge anyone with information to continue to report information about suspected drug dealing in their area, as this is vital to putting the picture together.
“Please call us with any information, no matter how trivial. If you don't want to talk to us, you can anonymously pass the information to Crimestoppers.”